Table 1.

Enzymes catalysing the reactions with highly significant centrality across species. All reactions with centrality p-values <0.025 in at least three of the following species: Bacillus subtilis (BS), Escherichia coli (EC), Saccharomyces cerevisiae (SC), Chlamydomonas reinhardtii (CR), Arabidopsis thaliana (AT) and Homo sapiens (HS). A checkmark indicates that the reaction catalysed by the enzyme has a significant centrality in the corresponding species; a hyphen indicates not significant; n.a. indicates the corresponding enzyme is not annotated for the species.

enzymeEC no.BSECSCCRATHSreferences
superoxide dismutase1.15.1.1n.a.[3638]
carbonic anhydrase4.2.1.1n.a.[3945]
l-arabinose isomerase5.3.1.4n.a.n.a.n.a.[46,47]
phosphoglycerate mutase5.4.2.1[4851]