Nanofilaments on glioblastoma exosomes revealed by peak force microscopy

Shivani Sharma, Kingshuk Das, JungReem Woo, James K. Gimzewski

Abstract

Exosomes are sub-100 nm extracellular vesicles secreted by normal and cancer cells. We present a high-resolution structure of previously unidentified nanofilaments on glioblastoma-derived exosomes, using nanoscale peak force imaging. These stiff, adhesive, trypsin- and RNAse-resistant surface nanofilaments add a new dimension to the current structural knowledge of exosome-mediated intercellular communication.

  • Received December 9, 2013.
  • Accepted December 12, 2013.
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